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Surprisingly, overexpression of either spliced XBP1 (XBP1s) or unspliced XBP1 (XBP1u) failed to re-sensitize IRE1-null MDA-MB-231 cells to ferroptosis induction (Fig

Unlike gels, which rely on diffusion across the cornea and conjunctivaoften resulting in low bioavailability and the need for frequent administration, MNs create microchannels that enhance drug permeability, ensuring optimal therapeutic outcomes [62]