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Moreover, the levels of vitamin C and paraoxonase 1 (PON1) activity were markedly lower in individuals with MDD than in control individuals [126]

Several studies have demonstrated that chronic inflammation leads to several diseases like atherosclerosis, heart disease, Alzheimers disease, asthma, rheumatoid arthritis (RA), acquired immune deficiency syndrome (AIDS), cancer, multiple sclerosis (MS), diabetes, infections (bacteria, fungi, parasites), gout, inflammatory bowel disease (IBD), aging, congestive heart failure (CHF), and other neurodegenerative diseases [3]

Here, we attempted to untangle this matter adopting a dual approach based on NMR-based metabolomics and UPLC/MS analysis to dissect the serum metabolomic pathways dysregulations in a cohort of PD patients characterized with motor, cognitive, dopaminergic treatment and nutritional assessments

In patients, however, the correlation suggests that this system may become critically limiting

Firstly, most existing studies focus on animal and cellular experiments and lack large-scale clinical trials