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A phase Ib/II study of eribulin (ERI) plus pembrolizumab (PEMBRO) in metastatic triple-negative breast cancer (mTNBC) (ENHANCE 1)

At the same time, transcription of the gene encoding fatty acid synthase, a multi-enzyme protein that catalyzes the synthesis of fatty acids, increases because ChREBP becomes active due to the removal of its inactivating phosphate group

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As a final step for an approach akin to tumor-agnostic therapy, NGS analysis can help identify melanocytic tumors with rare genetic signatures, andeven more importantmelanocytic tumors with a high TMB which should be definitely ascribed to the category of classical melanoma with the relative therapeutic options

Results reported in Fig