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Residues E259 and Q252 are highlighted in red

372 Ongoing studies are evaluating ipilimumab in combination with TMZ, bevacizumab, and other ICIs

[14] NAD + and NADP + bind within the active site within four regions with similar properties amongst IDH enzymes

Choi JS, Lee SJ, Christ GJ, Atala A, Yoo JJ

Etesian: a phase 2B study of the efficacy, safety and tolerability of AZD8233, a PCSK9-targeted antisense oligonucleotide, in patients with dyslipidemia [abstract]