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Affiliation: 1 DevelRx Ltd, Biocity, NG1 1GF Nottingham, UK Email: [email protected] ORCID: Affiliation: 1 DevelRx Ltd, Biocity, NG1 1GF Nottingham, UK 3 Department of Life Sciences, University of Bath, BA2 7AY Bath, UK Explor Neuroprot Ther

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This metabolite disruption extends to CAR-T therapy: ATB-induced loss of gut microbiome metabolic output (e.g., reduced inosine and IPA) correlates with diminished CD19-CAR-T efficacy in B cell malignancies, as metabolites like inosine are required to sustain CAR-T cell proliferation and IFN- production (279, 280)

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