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GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport

Authors contributions Conceptualization and methodoloy preparation, project administration, writing original draft: Kobayashi H Software preparation: Kobayashi H, Matsubara S, Yoshimoto C, Imanaka S Validation: Yoshimoto C, Shigetomi H, Imanaka S Formal analysis and investigation: Matsubara S, Yoshimoto C, Shigetomi H, Imanaka S Resources provided and supervision: Matsubara S Data curation: Matsubara S, Kobayashi H Writing, review, editing and visualization: Kobayashi H, Matsubara S, Yoshimoto C, Shigetomi H, Imanaka S Funding acquisition: Yoshimoto C Availability of data and materials Not applicable

Findlay S, Nair R, Merrill RA, et al

Proinflammatory cytokines serve as pivotal drivers of aging by initiating dysregulated inflammatory cascades, disrupting immune homeostasis, and triggering metabolic dysfunction, with their pathological effects manifesting across multiple biological scales, from subcellular processes to systemic pathophysiology