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As the dopamine-producing neurons in the substantia nigra are lost, the availability of therapeutic targets diminishes, while receptor desensitization and downregulation further impair drug effectiveness

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They spent the money, they got the patent

102 Based on this insight, we tested and confirmed the hypothesis that iron chelation prevents protein nitration in mitochondria and protects against APAP hepatotoxicity

Smaller support particles mean shorter diffusion distances, since they have shorter pores and a thinner stagnant mobile phase layer around and in the support