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Research show that FMT in mice, from young to old, can restore spermatogenic issues in aged mice through GPX4-induced ferroptosis caused by the intestinal metabolite 3-hydroxyphenylacetic acid (3-HPAA) [185]

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An alternative strategy could involve the understanding of the molecular mechanisms underlying the known risk factors and to correct them, when possible, as a prevention/treatment of the disease

10.1016/j.neuron.2018.11.018 Neuron 121 SiddiquiM

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