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One study of 48 children (mean age 7 years and 4 months) with ASD and language impairment split patients into two groups, one received 2mg/kg/day (up to 50mg max) leucovorin calcium (folinic acid calcium salt), the other received placebo

* Correspondence: Huibin Xu, [email protected]

[2] This would be consistent with the odd clinical picture reported a compound that increased daytime alertness and performance in the same studies where it was said to improve night sleep [7] looks more like a modulator of state regulation than a sedative

doi:10.1016/j.bbr.2009.07.020, PMID: 19643148 Kumar A, Garg R (2009) Protective effects of antidepressants against chronic fatigue syndrome-induced behavioral changes and biochemical alterations