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A study (Hambright et al., 2017) showed that GPX4-knockout AD mouse models exhibited reduced hippocampal and cortical neuronal proteins and increased LPO, which were reversed by the lipophilic antioxidant vitamin E

10.1016/j.biopha.2020.110465 201 YangT.RenC.QiaoP.HanX.WangL.LvS.et al (2018)

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Genotype and clinical phenotype in four patients with glutathione synthetase deficiency

Huichalaf C, Perfitt TL, Kuperman A, Gooch R, Kovi RC, Brenneman KA, Chen X, Hirenallur-Shanthappa D, Ma T, Assaf BT, Pardo I, Franks T, Monarski L, Cheng T-W, Le K, Su C, Somanathan S, Whiteley LO, Bulawa C, Pregel MJ, Martelli A