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Finally, the v-ATPase is also targeted in individuals with X-linked dominantly inherited ALS with FTD by mutation in the UBQLN2 gene (encoding ubiquilin 2) that functions in both the proteasome and autophagy pathways by clearing misfolded proteins 186

This review explores the link between circadian rhythms and tissue homeostasis, delving into their biological functions, including influences on metabolic homeostasis, neuroendocrine signaling, immune and oxidative stress responses, tissue repair, and autophagy activity