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All TrxR enzymes require an NADPH-dependent reduction step to exert their function in vivo and TrxR is a therapeutic target for cancer and infectious diseases 21,67

In clinical translation, therapeutic approaches targeting mutated mtDNA in tumors have progressed from broadly addressing mtDNA-associated metabolic pathways to focusing on specific mutations, consistent with the paradigm of precision oncology

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(also popularly known as amla) is a tree native to the India and Southeast Asia regions that produces fruits rich in bioactive compounds that could be explored as part of the increasing interest in naturally occurring compounds with biological activity