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Phosphorylated ERK and Akt can activate mTOR proteins, resulting in neurite outgrowth and neuronal survival [51]

11 The nonpeptide GLP-1 RA orforglipron (Foundayo) was approved in April 2026, becoming the second oral IBT available for chronic weight management

Christopher Azzoli, [email protected] This article was submitted to Pharmacology of Anti-Cancer Drugs, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers