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These include CTLA-4 mediated interference with antigen-presenting cell function to limit costimulatory signals [113], the secretion of anti-inflammatory cytokines that directly inhibit Th2 and Th17 proliferation and effector functions, and the constitutive expression of high CD25 levels, enabling competitive consumption of IL-2 and the restriction of effector T-cell expansion [114]

Collectively, these results indicate that PPARa protected neurons loss and promotes motor function recovery after TSCI by regulating FSP1 expression

Leito, A

Mrozek, E