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Premetastatic niches formation, ECM remodelling and angiogenesis The formation of premetastatic niches, tissue sites primed to support metastatic cell growth, represents a promising therapeutic strategy against tumour metastasis. Primary tumours release pro-inflammatory cytokines and chemokines that recruit myeloid-derived suppressor cells (MDSCs) to distant tissues, aiding metastatic cells even before their arrival

Abedin et al., 2002

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Low doses of GHB can cause nausea, while high doses can lead to: Unconsciousness Seizures Slowed heart rate Considerably slowed breathing Lower body temperature Vomiting Nausea Coma Death Alcohol worsens all of these symptoms and it can lead to an overdose

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