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After an interim analysis, mAb114 monotherapy and REGN-EB3 were both found to be superior to ZMapp with respect to the primary outcome and patient mortality 179 , and were approved by the FDA for the treatment of EVD in 2020 (refs 180,181 )

The animal studies used both local application at the injury site and systemic administration (intraperitoneal and intragastric), with both routes showing significant effects

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[6] A second study by Ionescu and Frohman gave a single injection to healthy men and showed that GH secretion rose driven mostly by a marked increase in trough GH while preserving the normal pulsatile pattern, with a corresponding rise in IGF-1