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It also raised levels of Th1-associated cytokines such as IFN-, IL-2, and TNF- and enhanced the growth of the CD8 + dendritic cell (DC), which exhibited higher expression of CD86 and CD80 molecules [101]

found that general control of amino acid synthesis 5 like 1 (GCN5L1) in mitochondria of liver cancer cells can promote the acetylation and inactivation of GLS1 and GLS2 isomers, thus inhibiting mTORC1 activation and cell proliferation

Copper is a pivotal trace element and a biologically active cofactor within the human body, exerting a critical influence on a multitude of physiological processes, including mitochondrial respiration, biosynthetic pathways and antioxidant defense mechanisms (1)

Its pleiotropic biological actionsincluding the stabilization of cellular energy homeostasis, regulation of redox balance, and modulation of mitochondrial dynamics and apoptotic pathwayshighlight its broad therapeutic potential