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Organelle-specific localization of glutathione in plants grown under different light intensities and spectra

So far, it appears that their role depends on the H 2 O 2 levels within RBC: CAT is crucial for scavenging high exogenous and endogenous peroxide levels, GPx and Prx2 are important for scavenging low endogenous and low peroxide levels

216 Carnosic acid enhances the sensitivity to cisplatin by decreasing cell viability and increasing ferroptosis, and this effect can be reversed by the ferroptosis inhibitor liproxstatin-1, suggesting that ferroptosis is involved in carnosic acid-mediated cisplatin resistance

This indicated the ancient evolution of these classes before the split of monocots-dicots

However, intracellular GSH at high concentrations inactivates ROS and reduces efficacy