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This immediate cellular damage is a critical trigger for subsequent tissue responses ( 2.2 Transition to chronic radiation skin injury and fibrosis The transition from acute to chronic radiation skin injury is a complex process marked by persistent inflammatory and fibrotic responses ( Epithelial cells in the skin may undergo an epithelialmesenchymal transition (EMT), particularly in scenarios of severe or repeated radiation exposure ( 3 Molecular mechanisms of fibrosis 3.1 Origin of myofibroblasts The origin of myofibroblasts, key effector cells in the development of radiation skin fibrosis, is a topic of significant interest and ongoing research in the field of fibrotic diseases

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