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In a related analysis, GHK was noted for its ability to reverse, in vitro, an aggressive gene-expression signature associated with metastatic behavior in certain tumor-cell datasets a striking observation that is nonetheless purely computational/in-vitro and not a therapeutic claim, and one that should be read alongside the founding finding that the same peptide can stimulate growth in neoplastic cells

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Research published in 2023 demonstrated that GHK-Cu significantly upregulates genes associated with collagen I and III synthesis while simultaneously modulating matrix metalloproteinase (MMP) activity [1]