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No perimenopause-specific contraindications identified beyond the above

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The study highlights that PEGylated PLGA nanoparticles, could offer a promising alternative for the safe delivery of tolcapone, maintaining its therapeutic effects while significantly reducing associated hepatotoxicity 129

Arch Med Sci 3:112116 Yang L, Licastro D, Cava E, Veronese N, Spelta F, Rizza W, Bertozzi B, Villareal DT, Hotamisligil GS, Holloszy JO, Fontana L (2016) Long-term calorie restriction enhances cellular quality-control processes in human skeletal muscle