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Torres et al., 2026)

Missense mutations in GPCRs can mislead protein folding and post-translational modifications to cause trafficking alterations, in which pharmacological chaperones are applicative therapeutic regimens

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From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration

Figure 1 Lactate also plays a role in enhancing neuronal excitability in the prefrontal cortex by modulating BK channels, specifically reducing the level of fast afterhyperpolarization (fAHP) during action potentials