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Biological evaluations included in vitro studies using neuroblastoma cells (SH-SY5Y) and human brain microvascular endothelial cells (HBMECs) to assess the ability of the nanoparticles to cross the BBB and effectively target neuronal cells

High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson disease

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Research suggests that Akt-mediated eNOS phosphorylation may increase nitric oxide (NO) bioavailability within vascular tissue microenvironments, potentially supporting vasodilation, microvascular integrity, and organized angiogenic responses in tissues with limited baseline vascular supply such as tendon, ligament, and fibrocartilaginous structures

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