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185 MaysamiS.NguyenD.ZobelF.PitzC.HeineS.HopfnerM.et al

In fact, there was a 2022 case report presented a 22-year-old student who exhibited hyperpigmentation as the only symptom of B12 deficiency

[DOI] [PubMed] [Google Scholar] 46.Kovacs D., Maresca V., Flori E., Mastrofrancesco A., Picardo M., Cardinali G

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The pineal gland acts as a neuroendocrine transducer since it manages its melatonin production based on the dark/light signal it receives from the central biological clock, the suprachiasmatic nucleus (SCN) in the hypothalamus [142, 143]