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Circadian dysregulation disrupts bile acid homeostasis

Beyond these, I/R injury can also develop in situations of trauma, shock, or sepsis, where systemic disruptions in blood flow to vital organs can precipitate tissue injury

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Additionally, reduced glutamine metabolism can lower the expression of immune checkpoint molecules (e.g., PD-1) on CD8+ T cells, thereby mitigating immune evasion within the TME (32)

Intervention in vascular remodeling is an important strategy to prevent and alleviate atherosclerosis