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Two studies investigated the ACC/mPFC and one of these studies found increased glutamine/glutamate ratio [40] while the other found no significant abnormalities in glutamate levels in schizophrenia [41]

Future research can focus on using specific gene knockout/knock-in animal models and combining single-cell sequencing technology to clarify the spatiotemporal expression patterns and functional differences of p53 in different cell types (such as chondrocytes, synoviocytes, and osteoclasts) and different stages of OA

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The development of solo therapies to treat both aspects of gliomas promises to yield more-effective treatment with fewer risks of toxicity and drug interactions