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doi: 10.1152/ajpregu.90974.2008 [DOI] [PubMed] [Google Scholar]

Post-stroke, the cGAS-STING signaling pathway is activated due to the mitochondrial DNA released from damaged cells, which leads to pro-inflammatory microglial activation and exacerbation of neuronal damage

Macrophages, on the other hand, can contribute to a microenvironment conducive to tumor growth, invasion into nearby tissues, and metastasis [146, 147]