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Indoxyl sulfate increases the gene expressions of TGF-beta 1, TIMP-1 and pro-alpha 1(I) collagen in uremic rat kidneys

Just like the blood-brain barrier (BBB), blood-labyrinthic barrier (BLB) can effectively isolate the blood from the inner ear labyrinth, preventing pathogens or toxic microorganisms from entering inner ear cells directly from the blood

Both studies were conducted in accordance with Good Clinical Practice, the Declaration of Helsinki and US Food and Drug Administration/European Medicines Agency guidelines for studies in people with renal or hepatic impairment [12,13,14,15]