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Nonetheless, these therapies still face difficulties in achieving specific delivery to organs, tissues and cells, which are exacerbated by the need to overcome multilevel biological barriers and intrinsically complex physiological disease characteristics

Wilcock, G

Specchio N, Wirrell EC, Scheffer IE, Nabbout R, Riney K, Samia P, et al

J.KlingerA

For example, in a preclinical study, curcumin was found to reduce levels of heat shock protein 27 (HSP27) and P-glycoprotein (P-gp), causing an increase in the sensitivity of colorectal cancer cells to the chemotherapeutic drug 5-fluorouracil (5-FU), which led to enhanced cell death in 5-FU-resistant HCT-8 cancer cells (He et al