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They can produce a temporary skin-brightening effect by reducing melanin production and oxidative stress but they dont permanently whiten skin, and results differ between individuals

Although various bio-safety evaluations have provided a series of evidences that MSNs are biocompatible in vivo within desirable dose and they can be degraded and expelled from the body via urine and feces 58,59,60,61 , there remain many challenges that need to be overcome since the in vivo therapeutic use requires more strict performance modulation to satisfy the complicated physiological environment so as to avoid unwanted bio-performances of MSNs

The conjugation is supervised by Atg7 and Atg3, which are ubiquitin-like enzymes [41]

gene locus Xq28) arranged in a 2:1:1 ratio ( 2+ , adenine dinucleotide phosphate (ADP), citrate) and negative effectors (ATP, NADH, NADPH)