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Furthermore, A is able to promote the hyperphosphorlyation of Tau in both the cytosolic and synaptic compartments, which has been suggested as a potential explanation of the prion-like seeding hypothesis of Tau transmission inter-neuronally, accounting for the phosphorylated Tau detected in the CSF of AD patients (Wu et al., 2018

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The morphologies of lyophilized hydrogels were examined by scanning electron microscopy (SEM, Hitachi S-3400N) at an accelerating voltage of 5 kV