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The disease is mediated by IgG Abs that bind components of the neuromuscular junctions

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NMN treatment has also demonstrated similar efficacy in a mouse model of myocardial fibrosis, reducing cardiac ejection fraction and aggravating myocardial fibrosis by upregulating cardiac cell SIRT6 protein expression (Yu et al., 2020)

The cell suspension was lysed on ice by sonication and the lysate was centrifuged at 17,000 g for 30 min at 4 C to remove the insoluble cellular debris