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Cullinan et al , 2003)

A single amino acid substitution converts -glutamyltranspeptidase to a class IV cephalosporin acylase (glutaryl-7-aminocephalosporanic acid acylase)

however, when DNA methylation occurs, the genes are silenced and the respective X-chromosome is inactivated [18]

Further, deletion of other POR electron acceptor proteins, such as heme oxygenase, cytochrome squalene monooxygenase, or cytochrome b5, did not affect ferroptosis sensitivity, suggesting that these other proteins downstream of POR also do not mediate the function of POR in ferroptosis regulation (Yan et al., 2020)