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Description

Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury

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Kovacs G, Billfeldt NK, Farkas N, Dergez T, Javorhazy A, Banyai D, et al

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Follow institutional laboratory protocols

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Solubility : Highly soluble in water (33 g/100 mL at 20C), slightly soluble in ethanol, and insoluble in nonpolar solvents like ether or chloroform

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Such uncoupling was also evidenced in vivo after chronic opioid agonist exposure

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