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Vitamin C serves as an essential cofactor for collagen production and can be obtained through diet or supplementation

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Previous studies have shown that SYNCRIP shuttles between the nucleus and cytoplasm [46], suggesting that the transcriptional and post-transcriptional functions of SYNCRIP are spatially coordinated across distinct cellular compartments

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Interestingly, this reduction in HK2 expression was accompanied by upregulation of GLUT1, an upstream regulator of HK2, suggesting a potential compensatory response to metabolic stress