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First, LCS3 treatment induced GSH inhibition in VRK2-KO cells, reflected by decreased levels of GSH/GSSG, whereas no significant effect on TXNRD1 activity was verified by the same concentration of LCS3

While the functions of the HEAT-repeats are relatively well-understood 21 , the roles of the IDR, due to its structural flexibility, which prevents its visualization in cryo-EM structures, remains largely unclear 20

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During this time, certain of the patients received the test alkanesulfonic acid compound, and others received the same alkanesulfonic acid concomitantly with donepezil, an acetylcholinesterase inhibitor

Circadian timekeeping in anticancer therapeutics: an emerging vista of chronopharmacology research