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In respect to vesicular release, it appears unlikely that filling of vesicles with ATP by VNUT is regulated by [ATP] c (at least for the physiological concentration range), given that VNUT is an active transporter and [ATP] c is rather high

There is abundant evidence of adverse health effects in all of these populations

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Firstly, combination therapy: The synergistic effects of combining these ESCM with conventional treatments (e.g., chemotherapy, radiotherapy, immunotherapy) should be investigated to enhance therapeutic efficacy and mitigate side effects