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Electrophysiology studies Current recordings were measured using two-electrode voltage clamp electrophysiology with an AxoClamp 900A microelectrode amplifier (Axon Instruments) and a PowerLab 4/26 chart recorder (ADInstruments) interfaced with LabChart software (version 8) (ADInstruments)
A prototypical example is the Zellweger spectrum disorders (ZSD), which arise from mutations in PEX genes encoding RING-type zinc finger peroxins such as PEX12 and PEX10, whose zinc-coordinating motifs are essential for peroxisome assembly and protein import 159,160
2009b May;127(5):674-680
