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Deficiency of selenium in serum or cytoplasm may impair the function of GPX4, eventually leading to the accumulation of lipid peroxides, which in turn leads to ferroptosis (Friedmann Angeli and Conrad, 2018)

Mutated GST sequences were subcloned into pET-15b, pET-24d, pGEX 4T-1, and pCMV-2B expression vectors, and the mutated constructs were confirmed by DNA sequencing

Nagaoka, and K

When 5-amino-1MQ increases cellular NAD+ levels, it enhances mitochondrial function, the powerhouses responsible for converting nutrients into usable cellular energy

SLC38A5 regulates tumor growth in vivo by mediating PI3K/AKT/mTOR signaling pathway and ferroptosis To delve deeper into the functions of SLC38A5 in vivo, we employed shSLC38A5 and shNC 143B cells to construct a subcutaneous xenograft model in BALB/c nude mice