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134 Notably, the concentrations of SPMs and IsoP that activate PPAR in vitro typically in micromolar range that markedly higher than their endogenous levels

Therefore, elucidating the molecular mechanisms underlying glial contributions to ALS pathogenesis is crucial for advancing our knowledge of the disease and the development of targeted therapeutic strategies

Regarding the triple combination, the pathways are highly similar to those of (M+D)/2, with an additional enrichment in pathways associated with anion transmembrane transporter activity ( Figure 7B )

Statistical analysis All data are presented as mean standard deviation (SD), and all statistical analyses were conducted using GraphPad Prism 10.6.0 software

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