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6 Targeting ROS or mitochondria in RA therapy drugs 6.1 Inhibition of inflammation Inhibition of inflammatory response is critical in the course of RA treatment, and biological agents, such as TNF- monoclonal antibodies, IL-6 monoclonal antibodies, and JAK pathway inhibitors, have been developed for inflammatory factors and have achieved significant clinical efficacy

selenium is a component of the antioxidant enzyme glutathione peroxidase, which helps to fight cell-damaging free-radicals

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(2012), which found a lower relative abundance of Roseburia and Eubacterium , recognized butyrate producers (Karlsson et al., 2012)

While the structural insights are unavailable, these observations denote highly specific substrate binding in the VhaA active site