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GSH represents the largest capacity thiol buffer in mammalian cells and plays a critical role in the detoxification of H 2 O 2 via GPx

doi: 10.3390/pharmaceutics16121556 87 AlharbiWSAlmughemFAAlmehmadyAMJarallahSJAlsharifWKAlzahraniNMet al

Lipopolysaccharide (LPS) binding to Toll-like receptor 4 (TLR4) on immune cells not only activates nuclear factor NF-B (NF-B) but also generates ROS that activate NADPH oxidase