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However, an overproduction of probiotic metabolites like peptidoglycan fragments or bacterial DNA can hyperactivate DCs via TLR2/9 or NOD2, boosting BAFF/APRIL production via NF-B/MAPK pathways, potentially triggering systemic autoreactive B cells and exacerbating SLE autoimmunity (139141)

The experimental work was mainly performed by MG

Pharmaceuticals , 18(2), 185

We transfected pHBV1.3 into Huh7 cells and found that LC3 conversion and p62 phosphorylation were upregulated (Fig

The SCFA-receptor interaction represents a direct molecular link in the gut-kidney axis, translating microbial metabolite production into renal protective signaling (Xiang et al., 2025)