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Interferon- (IFN-) and interleukin (IL)-15, through a JAK/STAT-mediated signaling response, promote activation and proliferation of autoreactive T cells.7 Moreover, TCR recognition of the autoantigen presented by the major histocompatibility complex (MHC) class I molecule on the epithelial cell of the HF triggers a T-cell signaling cascade involving TEC family kinases, which are crucial for T-cell differentiation and function.8 From a therapeutic perspective, there remains an unmet need for a treatment capable of inducing permanent or long-lasting remission

Depending on the treatment, you may need 3 to 6 sessions

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A 50 mM stock solution of dansyl chloride (Sigma-Aldrich, MO, USA) in DMSO was used