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*Correspondence: Zhigang Ren, [email protected] Yu, [email protected] These authors have contributed equally to this work This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The end result is an array of symptoms that can be debilitating