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For tissue extracts obtained from experiments on Langendorff hearts, the peak shapes and separation were affected by interfering contaminants, so to overcome this we modified the HPLC gradient as described in the Supplementary Table 4, keeping the rest of the parameters unchanged

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Using omics to define pathogenesis and biomarkers of Parkinson's disease

This was originally demonstrated for TRIM5 (Mandell et al., 2014), a protein that is known to assemble into a lattice around incoming retroviral cores in a host- and viral-species specific manner (Mandell et al., 2014