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In addition, a randomized controlled trial recruiting participants with newly diagnosed Alzheimers disease who consumed 1.25 mg/day of FA for 6 months showed that the intervention group had significantly higher scores on the mini-mental state examination, which may be associated with reduced levels of inflammation biomarkers TNF- and TNF--mRNA as well as Ab-related biomarkers Ab-40 and PS1-mRNA [130]

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Curr Opin Pharmacol 6(4):379386 Ip WKE et al (2017) Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

Some of the major pathways include excision repair (nucleotide excision repair [NER] and base excision repair [BER]) and recombinational (or double-strand break) repair (DSBR) [183]

This depletion can further exacerbate the vulnerability of neurons to oxidative stress, contributing to the onset of depressive symptoms