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There has also been a focus on combining this technique with other methods for enhanced epigenomics profiling: nanopore Cas9-targeted sequencing was used for assessing the methylation of O [6]-methylguanine-DNA methyltransferase (MGMT) while simultaneously detecting the isocitrate dehydrogenase (IDH) mutation status in glioma patients, and another method has been developed for concomitantly detecting CpG methylation and chromatin accessibility [6, 103]

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