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In cell-based assays, NCT-503 not only inhibited proliferation and induced apoptosis in multiple PHGDH-overexpressing cell lines but also blocked the incorporation of serine-derived carbon into nucleotides in both intracellular and extracellular contexts [9]

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This review described diverse PTMs of p53 in cancer, with a focus on how p53 and its PTMs participate in ferroptosis