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Gansemer et al., 2020), and its inhibition makes disulfide-bonded ER client proteins more sensitive to reduction (Gansemer et al., 2020)

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Importantly, different mtDNA mutations do not uniformly alter ROS production, and may variably affect ROS magnitude, species, and subcellular localization [278]

doi: 10.3389/fimmu.2025.1722463 Received 10 October 2025 Revised 03 December 2025 Accepted 12 December 2025 Published 12 January 2026 Volume 16 - 2025 Edited by Gabriella dEttorre, Sapienza University of Rome, Italy Reviewed by Christina K